Thursday, November 28, 2019
Monday, November 25, 2019
Learning From Poetry
Learning From Poetry Learning From Poetry Learning From Poetry By Erin No matter what kind of writing you do, reading poetry can be a great way to improve your writing skills. The principles of poetry can be applied to nearly every kind of writing you do. Lets take a look at what we can learn from poetry. 1. Poetry teaches word economy. In a poem, not a single word is wasted. Poets strive for finding the most effective words to convey each thought, emotion or idea. 2. Poetry uses powerful imagery. Poems are the epitome of show, dont tell. In a poem, you dont have a lot of time or space to spend narrating or telling the reader whats happening. Poets create strong visuals for their readers, truly giving the reader a glimpse of their subjects. 3. Poetry is inspiring. Love it or hate it, poetry elicits powerful emotions. A well-crafted line of poetry can stick with us for a long time. Sometimes, a poem or even just a memorable line, can make us want to write about that. The emotional response we have to the poem can often lead to an outlet for our own ideas. Resources There are a number of sites that offer daily poetry either delivered to your inbox or by RSS feed. The Writers Almanac from Garrison Keillor offers daily poems as well as historical information. Poetry Daily is another daily poem site. If you prefer, you can get get a haiku a day from Daily Haiku or tinywords. You can also check out any number of poetry anthologies. One of my favorites is Risking Everything, edited by Roger Housden. If you really hate poetry, try reading some Dr. Seuss or Shel Silverstein! You can also look to song lyrics, which have been a great source of inspiration for me. Want to improve your English in five minutes a day? Get a subscription and start receiving our writing tips and exercises daily! Keep learning! Browse the General category, check our popular posts, or choose a related post below:60 Synonyms for ââ¬Å"Walkâ⬠"Confused With" and "Confused About"Passed vs Past
Thursday, November 21, 2019
Introduction Essay Example | Topics and Well Written Essays - 250 words - 4
Introduction - Essay Example Quite successfully, the team came up with a barge design with Styrofoam, covered by wood. Many parameters like water resistance, speed and other stress load factors are considered to develop the design successfully. However, there will be a factor of uncertainty in the real world design (Ullman 314). A barge with rails, rope, claw and a hole-saw drill is the basic mechanical design for the floating Styrofoam salvage to transport the material. The claw is designed to catch the object under the water upon a trigger that is a simple electrical design. The hole saw drill has a threaded rod which again works on an electrical trigger. The movement of barge is made possible with a rope and rail mechanism. The prototype design was developed considering a water tank as the surrounding and limited environmental factors. The output that we obtained based on the design calculation was near to perfection, under the provided limited information. Considering the QFD process, the design planning process, the overall project performance taking into account the various parameters, gave a satisfactory results. Though the team was not working under a result-oriented platform, the conclusions that we could make on the design process turned out to be
Wednesday, November 20, 2019
In Fighting Obesity, are Calories, Carbohydrates or Fat Grams the Research Paper
In Fighting Obesity, are Calories, Carbohydrates or Fat Grams the Enemy - Research Paper Example population (Dietz, 2009). Research studies reveal that obesity is found to be associated with numerous chronic health states counting diabetes, stroke, heart diseases, high blood pressure (Glied, 2003). The number is increasing constantly and thereby obesity does not come alone but in association with other chronic conditions, radically enhancing the cost of healthcare. In order to afford the essential therapeutic concern and management, it requires to deal with comorbid states, resulting in the financial burden on the nation as well as deficit in upcoming healthcare endowment. Besides, an augmenting demands of health care facilities is observed, hence a complicated situation is portrayed. A more wide-ranging interdisciplinary research is required to have an insight to understand the situation (Glied, 2003). As obesity has emerged as an issue that is engulfing the well-being of individuals of the present epoch and is rising as an epidemic in the United States of America. The incidenc e of obesity amongst adults has become two fold in past couple of decades intensifying the health concern and related issues of the inhabitants (Flegal, 2010). Obesity condenses eminence of life, enhances the probability of untimely death, augments the jeopardy for numerous persistent diseases, related to heart such as coronary heart disease, hypertension, other related disorders like high cholesterol levels, sleep apnea, overweight resulting in orthopaedic problems, early signs of puberty in case of obese kids, reduced life expectancy, stroke, obesity enhances the possibilities of witnessing Type 2 diabetes, elevated BMI, cancer, arthritis, metabolic disorders and other related anomalies (US Department of Health and Human Services: The Surgeon Generalââ¬â¢s Call to Action to Prevent and Decrease Obesity). Obesity not only brings concern about health, but it adds to the financial burden too. Obesity augments the health care costs. Estimates reveal that obesity accounts for approx imately 10% of yearly medical expenses, increasing the obesity-associated medical costs to $147 billion in 2008 (Finkelstein. 2009). Obesity has reached an alarming position in USA, and two well distinguished categories have been demonstrated namely obese and extreme obese. Findings disclose that over one-third adults of United States are found to be obese during the year 2007ââ¬â2008 (Flegal, 2010). According to The National Health and Nutrition Examination Survey (NHANES), the incidence of obesity in the United States could be estimated by means of data for height to weight ratio. The prevalence rate of obesity displays that there was a steady increase in obesity equally in both the sexes belonging to all ages from 1976 -1980 to 1988-1994. On the other hand, the trend in obesity augmentation between 1988-1994 and 1999-2000 was significant in other ages except for the males belonging to the age between 40 to 59 years. While data analysis from 2001-2002 to 2003-2004 recommended escalating trends since 1999-2000 in males and not in females (Ogden, 2006).? Obesity trends also varies between the ethnic and racial communal groups which is displayed by means of BMI, a helpful tool to measure obesity for the examination and comparison of the obesity and to procure data in a standard format across the world as BMI indicates the percentage of body fat (Bouchard, 2008). Causes of Obesity As described by Glied,
Monday, November 18, 2019
International businesse in emerging market Assignment - 1
International businesse in emerging market - Assignment Example The emerging market accelerated growth of its international business, which were up 4% LFL. In June 2014, the company planned to invest $20 billion in a gas-fired power complex in Vietnam. In its planning, the company recognized the need to create a partnership with a host well-known company in Vietnam in an attempt to sell its products in this emerging market. It, therefore, collaborated with Vietnamââ¬â¢s state-owned petrol Vietnam. It erected two power plants with a capacity to produce between 6000 and 6500 megawatts of power. In this perspective, the company focuses on capturing the gas and oil market in Vietnam through provision of cheaper prices and diversified oil and gas brands (Regester & Larkin, 2014). It proposed to position its operation in 700 locations and several retail operations. In addition, the strategy aims to present its brands closer to consumers and therefore making its brand most accessible products in Vietnam. Vietnam is one of the top five developing nations in Asia. It has a robust middle class, a crucial driver of economic expansion in a developing country. It is valid to argue that middle class mainly supports the policy change significantly to the success of the country and in supporting capitalist democracy. The country has the fastest-growing middle class in the whole Southeast Asia and is expected to double in size from 12 million (2014) to 32 million by 2020. Generally, Exxon Mobil was experiencing various impending challenges in Vietnam such as complex foreign investment laws, corruption in infrastructure projects, lack of comprehensive and transparent legal system and restricted land usage rights (Plunkett, 2014). However, Vietnam is currently undergoing trade liberalization through negotiations toward a free agreement with the European Union (Van Dyke, et al., 2014). The negotiation presents viable market to Exxon Mobil since its
Friday, November 15, 2019
Rituximab Discovery Process
Rituximab Discovery Process Description of the Target Disease Rituximab (Rituxan) is a distinct monoclonal antibody for curing of non-Hodgkinââ¬â¢s lymphoma(NHL) or chronic lymphocytic leukemia. This drug is also used in conjunction with methotrexate to cure symptoms of rheumatoid arthritis. This form of cancer begins from the lymphatic system and extends all over the body. In this disease, tumor grows from lymphocytes-a variety of white blood cell. The lymphatic system is a fraction of the immune system and aids battle infections and other ailments in addition to sieving out bacteria. Clear liquid called lymph runs via the lymphatic vessels and have white blood cells called lymphocytes that fight infections (Kim 266). Although there are several diverse kinds of lymphoma that exist, this specific type is mostly widespread. The major indicator of the health is the presence of a bump in a lymph node. In the UK, over 11,000 infections of lymphoma are detected each year. Non-Hodgkinââ¬â¢s lymphoma is related with ageing as the chances of gett ing the illness increases with age and its typical age of detection is estimated at 65. While the root of the health condition is unidentified, the risk features of developing it consist of having a health condition that deteriorates the immune system, previous contact with high amounts of radiation and being formerly in contact with Epstein-Barr virus. The standard way to verify the presence of this form of lymphoma is by conducting a biopsy (investigation of infected lymph bump. Survival chances of a patient with illness differ significantly depending on the actual type, status and phase of the lymphoma. Rituximab (Rituxan) vaccine is used in the curing of lymphoma and was discerned at IDEC Pharmaceuticalsââ¬â¢ laboratories in 1991 and marketed by Genentech, a subordinate of Roche Group. The antibody was hereditarily engineered and used to generate high-yield expression structures. The US Food and Drug Administration (FDA) endorsed Rituximab in 1997 for curing this type of lymphoma. The vaccine received EU endorsement in June 1998 and sold under the brand name MabThera. On January 2011, the FDA endorsed Rituxan for treatment of superior follicular lymphoma (Carson et al. 820). Pharmaceutical Discovery Process of Rituxan As a curative IgG1 kappa antibody, Rituxan has mouse variable areas separated from anti-CD20 antibody. The antibody targets the lymphoma by binding itself with high resemblance to the cells having the CD20 antigen present on the exterior of normal B cells, excluding other regular cells. It mediates complement-reliant tissue lysis in the existence of human balance and antibody-reliant cellular cytotoxicity. The vaccine helps the immune system of the body to eradicate the stained CD20 B cells, reproduce new strong tissues from the lymphoid and takes them back to normal phases within a period of twelve months. In addition, the drug has been proven to stimulate apoptosis and modifies chemo-resistant lymphoma cells into in vitro (Ghetie et al. 1395). Clinical Phases of Rituximab Clinical trials are potential biomedical studies on human beings that are created to gather information about precise question on biomedical interventions. They are vital to the development of new drugs and vaccines used to prevent and cure diseases. Clinical researches are carried out to ascertain whether an innovative medication is secure and effective. Such studies are conducted after satisfactory information has been collected and approved by health authorities in the country of research. Ideally, clinical trials on new medicines comprises of four stages. Each phase of the procedure is regarded as a distinct clinical trial and the medicine development goes through all the stages over several years. After successfully proceeding through all the four phases, the drug is eventually endorsed by the regulatory authority for utilization in the whole population. The first phase of clinical development of Rituximab began in 1993. This phase involves the examination of biochemical effects of medicines on the body (pharmacodynamics) and the assessment of the body affects a drug (pharmacokinetics). In single-arm (pharmacodynamics) research, 166 patients who had B cell lymphoma were given four doses of 375 m/m2 of Rituxan as an intravenous infusion on weekly basis. Patients who had tumor of more than10cm in the marginal blood were not included in the study. It was observed that the infusion of Rituxan caused reduction of circulating B cells. Among the 166 patients infected with lymphoma, circulating B cells were lessened in the initial three weeks with continued reduction for 6 months following the treatment, in 83% of the patients. B cell revival began at about six months and the mean B cell levels went back to usual levels by 12 months after conclusion of treatment. It was also observed that there were continued and statistically considerable d epletion in serum levels from five to eleven months, after Rituximab administration Idusogie (Esohe et al. 1480). In pharmacokinetics study, 203 lymphoma patients were given four doses of 375mg/m2 Rituxan intravenous infusion on weekly basis. Rituxan was identified in the patientsââ¬â¢ serum within 3 to 6 months following conclusion of treatment. The pharmacokinetic outline of Rituximab when given in form of six infusions of 375mg/m2in conjunction with six doses of chemotherapy was comparable to that observed with Rituximab only. In accordance to 298 non-Hodgkinââ¬â¢s patients who were given Rituximab dose once weekly, scrutiny of information indicated that the median terminal eradication lifespan was twenty two days (series of 6 to 52 days). The patients who had more CD19 cell tally or bigger measurable tumor before treatment indicated higher clearance. Age and sex had no impact on the Rituximabââ¬â¢s pharmacokinetics (Byrd et al. 790). Patients were exposed to varying from a single mixture up to a period of two years. Rituxan was researched in single and regulated trials. Majority of the patients obtained 375mg/m2 of Rituxan infusion, provided as a solitary agent on weekly basis up to eight doses, in conjunction with eight doses of chemotherapy or 16 doses of chemotherapy. Many of the lymphoma patients reported various infusion reactions comprising of fever, nausea, angioedema, headache, rash, vomiting, pruritus, myaldia, bronchospasm and dizziness after the initial Rituxan infusion. The infusion responses generally happened in 30 to 120 minutes after the initial infusion and steadied with slowing of the Rituxan infusion coupled with helpful care. The occurrence of the infusion effects was highest at the in initial infusion (77%) and reduced gradually with each preceding infusion. Patients who previously had untreated health condition and did not show a rank 3 or 4 reaction associated with infusion in cycle 1 and obtained of 90 minutes Rituxan infusion at cycle 2, the occurrence of Grade3 to 4 infusion associated responses was 1.1% on or a day following the infusion. In cycles 2 to 8, the occurrence of Grade 3 to 4 infusion responses after the 90 minutes was 2.8% on or a day following the infusion (McLaughlin et al. 1765). Severe infections (Grade 3 or 4), consisting of sepsis, happened in not more than 5% of the lymphoma patients in the single-arm researches. The general occurrence of illnesses was 31% (viral 10%, unknown 6%, bacterial 19% and fungal 1%). In the haphazard regulated researches where Rituxan had been given after chemotherapy for the healing of the medical condition, non-Hodgkinââ¬â¢s lymphoma, the speed of infection was greater amongst the patients who had been given Rituxan. In scattered lymphoma patients with large B-cell, viral infections happened more repeatedly for those who had obtained Rituxan. For lymphoma patients who had been given Rituximab monotheraphy, 48% of them displayed cytopenias of score 3 and 4. These comprised lymphopenia (40%), thrombocytopenia (2%). leucopenia (4%) and neutropenia (6%) .The mean period was 14 days for lymphopenia (range, 1 to 588 days) and 13 days for neutropenia (range, 2 to 116 days). Further, a single incidence of red cell aplastic (transient anemia) and two incidences of hemolytic anemia after Rituxan treatment happened at some stages in the single-arm researches. In the researches of monotheraphy, induced B-cell reduction happened in 71% to 81% of the lymphoma patients. Reduced serum levels of IgM and IgG happened in 14% of the patients (Idusogie et al. 1487). In phase III of the clinical trials were based on primary Rituxan and maintenance. This clinical trial was carried out in an open and randomized way comprising of two treatment stages and 1217 non-Hodgkinââ¬â¢s patients were enrolled. The research assessed the safety of Rituxan when mixed with chemotherapy in curing patients possessed with the medical condition. The principal outcome gauge was to unearth the Progression Free Survival (PFS) duration from randomization to development, death or relapse. The secondary result measure consisted assessment of response paces, chemotherapy treatments mixed both with and devoid of Rituxan and event motivated endurance endpoints. For the initial treatment, eight doses of Rituxan mixed with diverse chemotherapy were utilized. Patients who reacted to the first treatment were dispersed to obtain Rituxan on one occasion in a period of two months, for duration of two years, as the only agent. The resulted obtained indicated that the prescription of Rituxan in conjunction with chemotherapy for the particular period multiplied twice the PFS in the lymphoma patients. The research also confirmed that the protection and effectiveness of 375mg/m2 Rituxan was constant in the subsequently utilized pivotal researches when utilized solely or in conjunction with chemotherapy unlike those who ceased receiving Rituxan. Patients who were given Rituxan showed Grade 2 infection. Grade 3 to 4 severe responses of small white blood cell tally and infections were reported to be advance in Rituxan group. Post Marketing Experience As these reactions are detailed willingly from a populace of tentative size, it is impossible to dependably approximate their frequency or develop an informal association to drug exposure. Choices to consider in these reactions when labeling are normally based on the following aspect: seriousness of response, incidence of reporting, or potency of causal attachment to Rituxan. There are no sufficient and well-regulated researches on the use of Rituximab in expectant. post marketing information pointed out that B lymphocytopenia cell typically enduring not more than six months can happen in infants subjected to Rituximab in the uterus. Rituximab was discovered in the serum of newborns after birth. NHL is a severe illness that necessitates treatment. Rituximab ought to be utilized only during pregnancy if the probable gain to the mother validates potential threat to the fetus. Reproduction researches in cynomolgus monkeys at motherly exposures comparable to human curative exposures indi cated no sign of teratogenic effects. Although B cell tissue was lessened in the progeny of treated monkeys, b cell tally returned to usual points after six months of delivery (Leget et al. 547). In the case of nursing mothers, it is unidentified whether Rituxan is produced into human milk. Published information proposes that antibodies present in breast milk stops from going into the infant circulations in significant amounts. FDA has not necessitated pediatric researches in Polyarticular Juvenile Idiopathic Arthritis (PJIA) people of ages below 16 years due to worry of potential extended immune suppression in the growing immature immune system. Therefore, the safety of Rituxan in people with pediatric condition has not been ascertained. Immunogenicity Just like with all curative proteins, there is a possibility of immunogenicity. The indentified occurrence of positivity of antibody in an assay is greatly reliant on various factors comprising assay sensitivity, sample handling, assay methodology, concomitant treatments, sample gathering timing and underlying ailment. Due to the above reasons, assessment of the occurrence of antibodies to Rituximab and to other results may be deceiving. While utilizing an ELISA assay, Human Anti-Chimerical Antibody (HACA) was observed in (1.1%) 4 of 436 people with the lymphoma acquiring sole-agent Rituxan. 75% of the patients had purposive clinical reaction (Leget et al. 549). After the successful completion of the clinical trials on November 26, 1997, the Food and Drug Administration endorsed Rituximab, for showing the presence of follicular lymphoma. It formed the foremost monoclonal antibody endorsed for curing of cancer and the foremost sole agent endorsed precisely for healing of the specific lymphoma. Rituximab in conjunction with chemotherapy (CHOP) is better to CHOP only in the curing of huge lymphoma cells and various forms of B-cell lymphomas. The appropriate intravenous dose of 375mg/m2 is four weekly infusions. Healing is endured and outpatient treatment is feasible. Severe incidences are mainly grade 1 and 2, happening mostly with the initial infusion. In phase II sole-agent, the overall reaction pace was 50% with 10 months mean time to progression in patients. The bigger multicenter clinical test of 166 patients, the general reaction tempo was 48% (6% complete and 42% incomplete reactions). The median duration of reaction was 11 months and 13 months for responders. Activity has also been observed in patients with huge disease. Rituximab, endorsed for curing cancer, is safe and valuable in treating people with the health condition (Jazirehi Benjamin 2120). Mechanism of Action Rituximab attaches itself particularly to the antigen CD20, (B-lymphocyte-restricted segregation antigen, Bp35), a transmembrane protein that has a molecular mass of about 35 kD centered on B-lymphocytes. In the particular lymphoma, the antigen is shown on 90% of the B cells. However, the antigen does not exist on hematopoietic cells, normal plasma tissues or pro-B cells. CD20 controls an initial stride in the activation procedure for tissue cycle initiation and segregation, and probably operates as a calcium ion path.CD20 is not eradicated from the cell exterior and is not internalized when the antibody starts binding. B cells function also in the pathogenesis of the disease, rheumatoid arthritis and are related to chronic synovitis. In this situation, B cells might be operating at multiple locations in the autoimmune process, going through generation of rheumatoid factor (RF), antigen presentation and other autoantibodies production. The Fab realm of Rituximab attaches to the antig en CD20 present on the disease and its domain enlists immune effectors roles to intervene B-cell into vitro. Probable means of cell lysis comprise of Antibody-Dependent Cell Mediated cytotoxicity (ADCC) and Complement-Dependent Cytotoxitiy (CDC) (Janas et al. 442). The antibody has been demonstrated to stimulate apoptosis in the B-cell lymphoma. During tissue cross-reactivity, it was noted that Rituximab attached on the lymphoid tissues in the thymus, and on greater part of B-lymphocytes in marginal lymph and blood lumps. Little binding was seen in the non-lymphoid cells examined. Rituxan Prescription Administration of Rituxan to patients can cause severe side effects, which can eventually lead to death. Infusion reactions are the major usual side effects that occur. Severe infusion responses normally happen within 24 hours of initial infusion. It is important for patients to receive medicines to aid in reducing the possibility of having adverse infusion reactions from doctors. Patients with adverse infusion reaction history and other severe infections must notify their physicians before obtaining Rituxan. In case of occurrence of symptoms such as rash, sudden cough, itchiness, weakness and palpitations, patients should contact their doctors to obtain medication immediately. Other adverse side effects encompass Hepatitis B Virus reactivation, severe skin reaction and Progressive Multifocal Leukoencephalopathy (PML). Rituxan is administered by intravenous infusion through a needle. Blood tests are normally performed to ensure that no conditions that can safe hinder use of Rituxan ( Grillo-Là ³pez Antonio 770). The success and effectiveness of Rituximab has resulted in the development of advance anti-CD20 monoclonal antibodies. The advance value of Rituximab has given it superior edge over other drugs available in the market for the healing of the lymphoma. Amid its enhanced binding effect to cancerous B cells, Rituximab continues to dominate the market. Works cited Byrd, John C., et al. Rituximab therapy in hematologic malignancy patients with circulating blood tumor cells: association with increased infusion-related side effects and rapid blood tumor clearance. Journal of Clinical Oncology 17.3 (1999): 791-791. Carson, Kenneth R., et al. Monoclonal antibody-associated progressive multifocal leucoencephalopathy in patients treated with rituximab, natalizumab, and efalizumab: a Review from the Research on Adverse Drug Events and Reports (RADAR) Project. The lancet oncology 10.8 (2009): 816-824. Ghetie, M. A., Bright, H., Vitetta, E. S. (2001). Homodimers but not monomers of Rituxan (chimeric anti-CD20) induce apoptosis in human B-lymphoma cells and synergize with a chemotherapeutic agent and an immunotoxin. Blood, 97(5), 1392-1398. Grillo-Là ³pez, Antonio J. Rituximab (Rituxanà ®/MabTheraà ®): the first decade (1993-2003). Expert review of anticancer therapy 3.6 (2003): 767-779. Janas, E., et al. Rituxan (antià ¢Ã¢â ¬Ã CD20 antibody)à ¢Ã¢â ¬Ã induced translocation of CD20 into lipid rafts is crucial for calcium influx and apoptosis. Clinical Experimental Immunology 139.3 (2005): 439-446. Jazirehi, Ali R., and Benjamin Bonavida. Cellular and molecular signal transduction pathways modulated by rituximab (rituxan, anti-CD20 mAb) in non-Hodgkins lymphoma: implications in chemosensitization and therapeutic intervention. Oncogene 24.13 (2005): 2121-2143. Kim, Julian A. Targeted therapies for the treatment of cancer. The American journal of surgery 186.3 (2003): 264-268. Leget, Gail A., and Myron S. Czuczman. Use of rituximab, the new FDA-approved antibody. Current opinion in oncology 10.6 (1998): 548-551. McLaughlin, Peter, et al. Clinical status and optimal use of rituximab for B-cell lymphomas. Oncology (Williston Park, NY) 12.12 (1998): 1763-9. Idusogie, Esohe E., et al. Mapping of the C1q binding site on rituxan, a chimeric antibody with a human IgG1 Fc. The Journal of Immunology 164.8 (2000): 4178-4184. Rapoport, A. P., et al. Autotransplantation for advanced lymphoma and Hodgkins disease followed by post-transplant rituxan/GM-CSF or radiotherapy and consolidation chemotherapy. Bone marrow transplantation 29.4 (2002): 303-312.
Wednesday, November 13, 2019
The Hoover Dam and Its Construction Essay -- Hoover Dam Research Paper
Outside of China, the United States is the most-dammed country on the planet. Counting only dams taller than fifty feet high, the U.S. has some 5,000 dams that range from giant hydroelectric dams such as the Grand Coulee in Washington State to flood control dams in the southeast and dams that provide water for irrigation in California. Overall the United States has as many as 2.5 million dams of one sort or another. The design and construction of many of these dams took place between 1930 and 1975. This 45 years period is known as the golden age of dam building, starting with the construction of the Hoover Dam beginning in 1931. By the 1970s the golden age of dam construction began to come to an end with increased concerns of the impacts of dams on their surroundings. To better understand this time period I will look at the construction of Hoover Dam during the 1930ââ¬â¢s followed by an examination many of todayââ¬â¢s arguments for and against dams [i]. The need for a dam on the Colorado River was known decades before construction actually began due to the numerous destructive floods of the Colorado River. A need for water and electricity was also discovered to help with the development of the West. But there were many factors standing in the way such a large-scale construction project. Finally, in 1927 a bill detailing the project passed in Congress. Many construction companies began to look over the proposals but most agreed that the plan was too ambitious, too difficult, the project site was too unforgiving, and that the technology was not available to build a dam of that size[ii]. Hoover Dam is located in the Black Canyon, on the Colorado River, about thirty miles southeast of Las V... ...onomic impacts of the dam, the impacts of removal, and the economic costs. Notes [i] Davy, Emma. ââ¬Å"Robofishâ⬠Current Science March 2, 2001: 10. [ii] http://www.hooverdam.usbr.gov/ [iii] http://xroads.virginia.edu/~MA98/haven/hoover/front2.html [iv] http://www.pbs.org/wgbh/amex/hoover/ 5 Robbins, Elaine. ââ¬Å"Damning Dams.â⬠E Jan 1999: 14. 6 Franklin, Chris. ââ¬Å"Let the Colorado River run free.â⬠Earth Island Journal Spring 1997: 23. 7 http://www/irn.org/ 8 ââ¬Å"Not so fast; Eliminating dams; Why dams can be green.â⬠The Economist March 3, 2001: 4. 9 Wade, Beth. ââ¬Å"Bringing down the dams.â⬠American City and County June 1999: 20. 10 ââ¬Å"Knocking down dams ââ¬â A good year for alewives.â⬠The Economist July 29, 2000: 32. 11 http://www.saveourdams.com/ 12 McMahon, Richard Jr. ââ¬Å"Letââ¬â¢s not damn the dams.â⬠The Business Journal January 28, 2000: 47.
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